Abstract: Corneal endothelial cell plays a key role in maintaining its transparency. Glaucoma and its treatment may cause damages to the corneal endothelial cells. Intraocular pressure, either too high or too low, could destroy the structure of corneal endothelial cells, as well as their pump function; the implantation and displacement of the drainage devices will damage the corneal endothelial cells; the imbalance of aqueous humor microenvironment will influence the nutrition supply to corneal endothelial cells; the toxicity of anti-glaucoma medicines may contribute to the dysfunction of corneal endothelial cells. This paper summarizes the relevant clinical and basic researches, and discusses the corneal injury mechanisms, aiming to provide guidances for the diagnosis and treatments of glaucoma, and reduce or avoid the visual function damages caused by corneal endothelial cell injury in glaucoma patients. (Int Rev Ophthalmol, 2022, 46:  541-546)

Key words: glaucoma, corneal endothelial cells, injury